Cis-interactions between Notch and its ligands block ligand-independent Notch activity
The Notch pathway is integrated susanne kaufmann vitamin c complex into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation.Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands)